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Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production.
Developmental cell 2021 Mar 08Sizes of these terms reflect their relevance to your search.
In this issue of Developmental Cell, Weinreb et al. reveal that loss of the DEAD-box helicase Ddx41 unexpectedly triggers an R-loop-mediated sterile inflammatory cascade which drives HSPC production during embryonic development. Human studies suggest mechanistic conservation for inflammation in DDX41-associated hematologic disease, uncovering a potential route for future therapeutic intervention. Copyright © 2021 Elsevier Inc. All rights reserved.
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Jenna M Frame, Trista E North. Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production. Developmental cell. 2021 Mar 08;56(5):571-572
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PMID: 33689767
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