A new layer of the Golgi complex: Membrane trafficking, glycosylation, and signaling transduction.

The Golgi complex plays a central role in the secretory pathway by regulating sorting, trafficking, and post-translational modification of secretory cargoes. It is structurally a unique organelle, consisting of several stacks known as cisternae. Morphologic changes of the Golgi complex have been found in various physiological and pathological conditions including cancer, immunodeficiency, and neurodegenerative diseases. These changes lead to functional alterations of glycosylation and membrane trafficking of secretory proteins. How Golgi complex contributes to many cellular events remains a long-standing question. Here, we summarize the journey to the understanding of the Golgi complex. Molecular mechanisms and physiologic importance of the secretory pathway and post-translation modification are reviewed. Recent findings of multiple signaling pathways regulated by the Golgi complex to maintain organelle homeostasis are also summarized.

Citation

Kunyou Park, Sung-Eun Ju, Nari Kim, Seung-Yeol Park. A new layer of the Golgi complex: Membrane trafficking, glycosylation, and signaling transduction. BMB reports. 2021 Mar 11

PMID: 33691906

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