Correlation Engine 2.0
Clear Search sequence regions

  • balloon (2)
  • bone cements (7)
  • humans (1)
  • methyl (4)
  • Sizes of these terms reflect their relevance to your search.

    In spite of the success of vertebroplasty (VP) and balloon kyphoplasty (BKP), which are widely used for stabilizing painful vertebral compression fractures, concerns have been raised about use of poly(methyl methacrylate) (PMMA) bone cements for these procedures since the high compressive modulus of elasticity (E) of the cement is thought to be one of the causes of the higher number of adjacent-level vertebral fractures. Therefore, bone cements with E comparable to that of cancellous bone have been proposed. While the quasi-static compressive properties of these so-called "low-modulus" cements have been widely studied, their fatigue performance remains underassessed. The purpose of the present study was to critically compare a commercial bone cement (control cement) and its low-modulus counterpart on the basis of quasi-static compressive strength (CS), E, fatigue limit under compression-compression loading, and release of methyl methacrylate (MMA). At 24 h, mean CS and E of the low-modulus material were 72% and 77% lower than those of the control cement, whereas, at 4 weeks, mean CS and E were 60% and 54% lower, respectively. The fatigue limit of the control cement was estimated to be 43-45 MPa compared to 3-5 MPa for the low-modulus cement. The low-modulus cement showed an initial burst release of MMA after 24 h followed by a plateau, similar to many other commercially available cements, whereas the control cement showed a much lower, stable release from day 1 and up to 1 week. The low-modulus cement may be a promising alternative to currently available PMMA bone cements, with the potential for reducing the incidence of adjacent fractures following VP/BKP. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.


    Céline Robo, Caroline Öhman-Mägi, Cecilia Persson. Long-term mechanical properties of a novel low-modulus bone cement for the treatment of osteoporotic vertebral compression fractures. Journal of the mechanical behavior of biomedical materials. 2021 Jun;118:104437

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33706086

    View Full Text