Liver X receptors and liver physiology.

Lillian Russo-Savage, Ira G Schulman

Biochimica et biophysica acta. Molecular basis of disease 2021 Jun 01

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The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid homeostasis throughout the body. This review focuses on the control of cholesterol and fatty acid metabolism by LXRs in the liver and how modifying LXR activity can influence the pathology of liver diseases. Copyright © 2021. Published by Elsevier B.V.

Citation

Lillian Russo-Savage, Ira G Schulman. Liver X receptors and liver physiology. Biochimica et biophysica acta. Molecular basis of disease. 2021 Jun 01;1867(6):166121