Correlation Engine 2.0
Clear Search sequence regions

  • bile (4)
  • bile acids (12)
  • bile acids salts (1)
  • bile salt (2)
  • BSEP (1)
  • cholestasis (1)
  • humans (4)
  • liver (3)
  • Mdr2 (1)
  • phospholipids (1)
  • salts (1)
  • Sizes of these terms reflect their relevance to your search.

    Bile acids are key components of bile required for human health. In humans and mice, conditions of reduced bile flow, cholestasis, induce bile acid detoxification by producing tetrahydroxylated bile acids (THBA), more hydrophilic and less cytotoxic than the usual bile acids, which are typically di- or tri-hydroxylated. Mice deficient in the Bile Salt Export Pump (Bsep, or Abcb11), the primary bile acid transporter in liver cells, produce high levels of THBA, and avoid the severe liver damage typically seen in humans with BSEP deficiencies. THBA can suppress bile acid-induced liver damage in Mdr2-deficient mice, caused by their lack of phospholipids in bile exposing their biliary tracts to unbound bile acids. Here we review THBA-related works in both animals and humans, and discuss their potential relevance and applications as a class of functional bile acids. Copyright © 2021 Elsevier B.V. All rights reserved.


    Jonathan A Sheps, Renxue Wang, Jianshe Wang, Victor Ling. The protective role of hydrophilic tetrahydroxylated bile acids (THBA). Biochimica et biophysica acta. Molecular and cell biology of lipids. 2021 Jul;1866(7):158925

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33713832

    View Full Text