PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities.

Biofouling 2021 Feb

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Adhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by Candida albicans. The ability of (PhSe)2 and (pCl-PhSe)2, two synthetic organic selenium (organochalcogen) compounds, to act on C. albicans virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was analyzed. Both organochalcogen compounds inhibited C. albicans adhesion to HeLa cells, dependent on compound concentrations. (PhSe)2 (at 20 µM; p = 0.0012) was significantly more effective than (pCl-PhSe)2 (at 20 µM; p = 0.0183) compared with the control. (PhSe)2 inhibited biofilm formation and decreased biofilm viability in both early and mature biofilms more efficiently than (pCl-PhSe)2. Overall, the organochalcogen compounds, especially (PhSe)2, were demonstrated to be effective antifungal drugs against C. albicans virulence factors related to epithelial cell surface adhesion and the formation and viability of biofilms.

Citation

Bruna Marques da Silva, Marília Toledo Braga, Juliene Cristina da Silva Passos, Moisés Lopes Carvalho, Isabela Bueno Rosseti, Laís Mayara Machado de Amorim, João Batista Teixeira da Rocha, Carlos Alberto-Silva, Maricilia Silva Costa. PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities. Biofouling. 2021 Feb;37(2):235-245