Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes.

Four new resorcinol derivatives, namely (-)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (-)-1 by chiral HPLC. The neuroprotective effects of 1-3 against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated.

Citation

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu, Xian Wang. Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes. Natural product research. 2022 Mar;36(6):1522-1528

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PMID: 33715538

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