Vigabatrin-associated Reversible MRI Abnormalities in an Infant with Tuberous Sclerosis.

Joseph Franklin Craft, Agustin M Cardenas

Journal of radiology case reports 2021 Feb

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Vigabatrin therapy is commonly used in infants diagnosed with tuberous sclerosis complex, particularly in the setting of epilepsy. Utilization of vigabatrin can result in bilateral and symmetric abnormal sequence changes within the deep brain matter and brainstem on magnetic resonance imaging. These abnormalities occur predominantly in infancy, are reversible, and can be asymptomatic or result in symptomatic clinical manifestations. We present a case with classic neuroimaging findings. Familiarity with these findings can prevent unnecessary follow up tests or studies and the cost of continuing or discontinuing vigabatrin therapy should be weighed heavily against the potential manifestation of extrapyramidal symptoms. Copyright Journal of Radiology Case Reports.

Citation

Joseph Franklin Craft, Agustin M Cardenas. Vigabatrin-associated Reversible MRI Abnormalities in an Infant with Tuberous Sclerosis. Journal of radiology case reports. 2021 Feb;15(2):1-6