Gastric acid suppression and antibiotic resistance; the role of a meta-analysis].

M J M Bonten, C H van Werkhoven

Nederlands tijdschrift voor geneeskunde 2021 Mar 11

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We discuss a meta-analysis that reported on the association between gastric acid suppression and carriage with antibiotic resistant bacteria, with a special focus on the association for carriage with ESBL-producing Gram-negative bacteria in non-hospitalized subjects. Results from a recent population-based study (not included in the meta-analysis) were added to this subgroup of the meta-analysis. The data point to a positive, yet minor, association between gastric acid suppression and carriage with ESBL-producing Gram-negative bacteria in non-hospitalized subjects in the Netherlands.

Citation

M J M Bonten, C H van Werkhoven. Gastric acid suppression and antibiotic resistance; the role of a meta-analysis]. Nederlands tijdschrift voor geneeskunde. 2021 Mar 11;165