Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer.

Telomerases are attractive targets for development of new anticancer agents. Most tumors express the enzyme telomerase that maintains telomere length and thus ensures indefinite cell proliferation, a hallmark of cancer. Curcumin has been shown to be effective against several types of malignancies and has also been shown to have inhibitory effects on telomerase activity. Hence, the aim of this chapter is to review the available investigations of curcumin on telomerase activity. Based on the findings obtained from the different studies here, we conclude that the telomerase inhibitory effects of curcumin are integral to its anticancer activity, and thus curcumin may be useful therapeutically in the cancer field.

Citation

Fatemeh Forouzanfar, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar. Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer. Advances in experimental medicine and biology. 2021;1286:135-143

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PMID: 33725351

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