Clear Search sequence regions


  • behaviours (1)
  • humans (1)
  • patients (2)
  • vertebrate (1)
  • zebrafish (5)
  • Sizes of these terms reflect their relevance to your search.

    The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judgement bias experimental paradigm to measure subjective evaluations of ambiguous stimuli in zebrafish. This behavioural assay allows classification of individuals in an optimistic-pessimistic dimension (i.e. from individuals that consistently evaluate ambiguous stimuli as negative to others that perceive them as positive). Using this behavioural paradigm we found that telomerase-deficient zebrafish (tert-/-) were more pessimistic in response to ambiguous stimuli than wild-type zebrafish. The fact that individuals with constitutive shorter telomeres have pessimistic behaviours demonstrates for the first time in a vertebrate model a genetic basis of judgement bias.

    Citation

    F Espigares, D Abad-Tortosa, S A M Varela, M G Ferreira, R F Oliveira. Short telomeres drive pessimistic judgement bias in zebrafish. Biology letters. 2021 Mar;17(3):20200745

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33726560

    View Full Text