Shangwen He, Ting Cai, Juanjuan Yuan, Xiaojun Zheng, Wei Yang
Advances in experimental medicine and biology 2021T cells recognize "foreign" antigens and induce durable humoral and cellular immune responses, which are indispensable for defending pathogens, as well as maintaining the integrity and homeostasis of tissues and organs. T cells are the major immune cell population in the tumor microenvironment which play a critical role in the antitumor immune response and cancer immune surveillance. Defective immune response of tumor-infiltrating T cells is the main cause of cancer immune evasion. The antitumor response of T cells is affected by multiple factors in the tumor microenvironment, including immunosuppressive cells, immune inhibitory cytokines, tumor-derived suppressive signals like PD-L1, immnuogenicity of tumor cells, as well as metabolic factors like hypoxia and nutrient deprivation. Abundant studies in past decades have proved the metabolic regulations of the immune response of T cells and the tumor-infiltrating T cells. In this chapter, we will discuss the regulations of the antitumor response of tumor-infiltrating T cells by lipid metabolism, which is one of the main components of metabolic regulation.
Shangwen He, Ting Cai, Juanjuan Yuan, Xiaojun Zheng, Wei Yang. Lipid Metabolism in Tumor-Infiltrating T Cells. Advances in experimental medicine and biology. 2021;1316:149-167
PMID: 33740249
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