Weight loss and its influence on high-density lipoprotein cholesterol (HDL-C) concentrations: A noble clinical hesitation.

Heitor O Santos, Carl J Lavie

Clinical nutrition ESPEN 2021 Apr

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The relationship between obesity, weight loss, and high-density lipoprotein cholesterol (HDL-C) is poorly recognized and understood. Through an emphasis on current studies, in this viewpoint, we provide further scientific and medical considerations on the relationship between weight loss and the management of HDL-C levels. Long-term adherence to a low-calorie diet is a determinant of weight loss, with weight loss and/or normal weight being important clinical conditions to lower risk for the development of cardiometabolic dysregulations and cardiovascular diseases. These benefits appear to be independent of variations in serum lipids and lipoproteins. Indeed, there is a paradoxical link between weight loss and HDL-C levels, which can result in both increases and reductions in the concentrations of this recognized biomarker of cardiovascular health. Care should be exercised in order to avoid overvalued clinical recommendations in the management of HDL-C levels. Further hesitation is needed for health practitioners as well as skepticism surrounding science. Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

Citation

Heitor O Santos, Carl J Lavie. Weight loss and its influence on high-density lipoprotein cholesterol (HDL-C) concentrations: A noble clinical hesitation. Clinical nutrition ESPEN. 2021 Apr;42:90-92