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Type II diabetes mellitus is a known cardiovascular risk factor and its prevalence continues to increase. A revolution in the Type II diabetes mellitus treatment has occurred with the arrival of new antidiabetic drugs, which are thought to compromise metformin place. We aim to review the pharmacology, available evidence and clinical aspects of metformin use in the era of new antidiabetics.


Ez Alddin Rajjoub Al-Mahdi, Vivencio Barrios, Jose L Zamorano. Metformin in the era of new antidiabetics. Future cardiology. 2021 May;17(3):475-485

PMID: 33754810

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