The dynamic instability of actin filament barbed ends.

Guillaume Romet-Lemonne, Antoine Jégou

The Journal of cell biology 2021 Apr 05

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The turnover of actin filament networks in cells has long been considered to reflect the treadmilling behavior of pure actin filaments in vitro, where only the pointed ends depolymerize. Newly discovered molecular mechanisms challenge this notion, as they provide evidence of situations in which growing and depolymerizing barbed ends coexist. © 2021 Romet-Lemonne and Jégou.