Untangling the crosstalk between BRCA1 and R-loops during DNA repair.

Marta San Martin Alonso, Sylvie M Noordermeer

Nucleic acids research 2021 May 21

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R-loops are RNA:DNA hybrids assembled during biological processes but are also linked to genetic instability when formed out of their natural context. Emerging evidence suggests that the repair of DNA double-strand breaks requires the formation of a transient R-loop, which eventually must be removed to guarantee a correct repair process. The multifaceted BRCA1 protein has been shown to be recruited at this specific break-induced R-loop, and it facilitates mechanisms in order to regulate R-loop removal. In this review, we discuss the different potential roles of BRCA1 in R-loop homeostasis during DNA repair and how these processes ensure faithful DSB repair. © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

Citation

Marta San Martin Alonso, Sylvie M Noordermeer. Untangling the crosstalk between BRCA1 and R-loops during DNA repair. Nucleic acids research. 2021 May 21;49(9):4848-4863