Predicting viable skin concentration: Diffusional and convective drug transport.

Viable skin drug transport is an important concept to consider as it can have a significant impact on the local concentration of a drug. The concentration becomes even more critical for toxicological issues when implementing different permeability enhancement techniques. For this reason, it is important to develop models that can predict drug transport in the viable skin. This paper expands upon previous capillary modeling by representing the convective transport of a solute that has permeated into the capillary loops. As a result, convective transport caused the concentration profile to plateau within the deeper dermal layers, effectively matching the trend of previous experimental data. Furthermore, the new model also has a significantly quicker transient profile as the time required to reach steady-state is five-fold faster than predicted in previous homogenous models. Copyright © 2021. Published by Elsevier Inc.

Citation

Joshua J Calcutt, Yuri G Anissimov. Predicting viable skin concentration: Diffusional and convective drug transport. Journal of pharmaceutical sciences. 2021 Jul;110(7):2823-2832

Mesh Tags

Substances

PMID: 33762180

search → result