Clear Search sequence regions


  • action research (1)
  • adult (4)
  • android (1)
  • caralluma (11)
  • humans (1)
  • insulin (1)
  • leptin (5)
  • lipid (1)
  • mass (5)
  • men (1)
  • overweight (4)
  • placebo (9)
  • placebo effect (1)
  • plant extracts (2)
  • plasma (2)
  • receptor (1)
  • waist circumference (2)
  • weight (1)
  • weight gain (1)
  • weight loss (1)
  • women (1)
  • young adult (1)
  • Sizes of these terms reflect their relevance to your search.

    To examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. A double-blind, randomised, placebo controlled trial to examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. Eighty-three men and women aged between 20 and 50 years of age completed 16 weeks of daily supplementation with either CFE or placebo. Plasma cardiometabolic (lipid profile, glucose, insulin) and satiety (ghrelin, leptin, neuropeptideY) biomarkers, body composition, diet history and gastrointenstinal function were assessed at baseline, weeks 4, 8, 12 and 16. Subjects in the CFE and placebo groups were well matched and predominatly female 93% and 87.5%, with a mean age of 40.9 ± 6.7 and 39.5 ± 7.5 years and body mass index (BMI) of 30.0 ± 3.1 and 30.2 ± 2.9 kg/m2 respectively. There was a significant difference in plasma leptin concentration change between groups at week 16 (p = 0.04), with the placebo group increasing concentration (2.27 ± 4.80 ng/mL) while the CFE group (0.05 ± 4.69 ng/mL) remained the same. At week 16, the CFE group had significantly reduced their calorie intake from baseline compared to the placebo group (245 cal vs 15.8 cal respectively p < 0.01). The CFE group also had a significant reduction in waist circumference of 2.7 cm compared to an increase of 0.3 cm in the placebo group (p = 0.02). A weight increase from baseline was seen in the placebo group that was not observed in the CFE group (1.33 kg weight gain vs 0.37 kg weight loss respectively; p = 0.03). The placebo group also had a significant increase in fat mass, android fat mass, BMI and leptin compared to the CFE group (p = 0.04, 0.02, < 0.01 respectively). CFE was effective at maintaining bodyweight during a non-calorie controlled diet compared to a placebo. The mechanism responsible for this action is requiring further research and could be due to an increase in satiety receptor sensitivity.

    Citation

    Amanda Rao, David Briskey, Carla Dos Reis, Alistair R Mallard. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults. Scientific reports. 2021 Mar 24;11(1):6791

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33762661

    View Full Text