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    Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.See related article by Paradis et al., p. 3190. ©2021 American Association for Cancer Research.

    Citation

    J William Harbour. Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Mar 25


    PMID: 33766812

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