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The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin-Sca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes Lin-CD122+CD49a+ progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR+ liver progenitors. Thus, an IFN-γ-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver. Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.


Lu Bai, Margaux Vienne, Ling Tang, Yann Kerdiles, Marion Etiennot, Bertrand Escalière, Justine Galluso, Haiming Wei, Rui Sun, Eric Vivier, Hui Peng, Zhigang Tian. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science (New York, N.Y.). 2021 Mar 26;371(6536)

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PMID: 33766856

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