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Migraine afflicts more than one billion individuals worldwide and is a leading cause of years lived with disability. In about a third of individuals with migraine aura occur in relation to migraine headache. The common pathophysiological mechanisms underlying migraine headache and migraine aura are yet to be identified. Based on recent data, we hypothesized that levcromakalim, an ATP-sensitive potassium channel opener, would trigger migraine attacks with aura in migraine with aura patients. © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email:


Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Cherie Amalie Waldorff Nielsen, Anders Hougaard, Messoud Ashina. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain : a journal of neurology. 2021 Mar 26

PMID: 33768245

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