The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue.

Anticancer research 2021 Mar

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Hepatocellular carcinoma (HCC) remains one of the biggest medical issues. Pigment epithelial-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors. PEDF interacts with its two receptors, adipose triglyceride lipase (ATGL) and laminin receptor (LR). We conducted immunohistochemical staining for PEDF, LR and ATGL in 151 resected HCCs and their background liver tissues. High expression of LR in HCC was associated with high histological grade and portal vein invasion, while high expression of PEDF in HCC was associated with absence of portal vein invasion. High LR expression in background liver was statistically associated with low serum albumin levels and was an independent prognostic factor of worse outcomes. No cases with more than 5% fatty degeneration in the background liver tissue showed high PEDF expression. PEDF/LR/ATGL could be potential biomarkers in HCC and various chronic hepatic disorders. Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Jun Akiba, Takafumi Yoshida, Eiji Sadashima, Kazuya Murata, Takanori Matsui, Sho-Ichi Yamagishi, Hironori Kusano, Yutaro Mihara, Shinji Mizuochi, Yoshinao Kinjou, Yoshiki Naito, Toru Hisaka, Hisamune Sakai, Koji Okuda, Osamu Nakashima, Hirohisa Yano. The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue. Anticancer research. 2021 Mar;41(3):1203-1212