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    It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) and T cells. We refer to these as the immunome. Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome. Copyright © 2021 Arnaout, Prak, Schwab, Rubelt and the Adaptive Immune Receptor Repertoire Community.


    Ramy A Arnaout, Eline T Luning Prak, Nicholas Schwab, Florian Rubelt, Adaptive Immune Receptor Repertoire Community. The Future of Blood Testing Is the Immunome. Frontiers in immunology. 2021;12:626793

    PMID: 33790897

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