Molecular profile of oral fluid in new coronavirus infection.

F N Gilmiyarova, O A Gusyakova, D Y Konstantinov, I A Selezneva, I A Borodina, N A Kolotyeva, E A Konstantinova, V S Tlustenko, S S Lebedeva, E I Temnik, V V Remizov

Klinicheskaia laboratornaia diagnostika 2021 Mar 30

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Oral fluid is an alternative biological material that confirms correlations with blood parameters in various pathological conditions of the body. In order to find a non-invasive approach to stratification of patients with COVID-19 disease, molecular biomarkers of the oral fluid have been determined in patients with moderate coronavirus infection in comparison with clinically healthy individuals. It has been shown that proteomic, carbohydrate, macro- and microelement profiles of the oral fluid in coronavirus infection can be used for diagnostics. The features of protein metabolism were revealed: an increase in the content of total protein, urea; increased activity of enzymes aspartate aminotransferase, gamma glutamyl transpeptidase, creatine phosphokinase, alkaline phosphatase; changes in carbohydrate metabolism, which is expressed by an increase in glucose and lactate levels, an increase in lactate dehydrogenase activity, sodium, chloride, calcium, magnesium, iron content.

Citation

F N Gilmiyarova, O A Gusyakova, D Y Konstantinov, I A Selezneva, I A Borodina, N A Kolotyeva, E A Konstantinova, V S Tlustenko, S S Lebedeva, E I Temnik, V V Remizov. Molecular profile of oral fluid in new coronavirus infection. Klinicheskaia laboratornaia diagnostika. 2021 Mar 30;66(3):133-138