Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice.

We report optical coherence tomography (OCT) imaging of localized fast optical signals (FOSs) arising from whisker stimulation in awake mice. The activated voxels were identified by fitting the OCT intensity signal time course with a response function over a time scale of a few hundred milliseconds after the whisker stimulation. The significantly activated voxels were shown to be localized to the expected brain region for whisker stimulation. The ability to detect functional stimulus-evoked, depth-resolved FOS with intrinsic contrast from the cortex provides a new tool for neural activity studies.

Citation

Jianbo Tang, Xiaojun Cheng, Kivilcim Kilic, Anna Devor, Jonghwan Lee, David A Boas. Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice. Optics letters. 2021 Apr 01;46(7):1744-1747

PMID: 33793533

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