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Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration. Copyright © 2021 Elsevier Ltd. All rights reserved.


Ana-Maria Raicu, Kalynn M Bird, David N Arnosti. Tête-à-tête with CtBP dimers. Structure (London, England : 1993). 2021 Apr 01;29(4):307-309

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PMID: 33798426

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