Migraine: Calcium Channels and Glia.

Marta Kowalska, Michał Prendecki, Thomas Piekut, Wojciech Kozubski, Jolanta Dorszewska

International journal of molecular sciences 2021 Mar 07

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Migraine is a common neurological disease that affects about 11% of the adult population. The disease is divided into two main clinical subtypes: migraine with aura and migraine without aura. According to the neurovascular theory of migraine, the activation of the trigeminovascular system (TGVS) and the release of numerous neuropeptides, including calcitonin gene-related peptide (CGRP) are involved in headache pathogenesis. TGVS can be activated by cortical spreading depression (CSD), a phenomenon responsible for the aura. The mechanism of CSD, stemming in part from aberrant interactions between neurons and glia have been studied in models of familial hemiplegic migraine (FHM), a rare monogenic form of migraine with aura. The present review focuses on those interactions, especially as seen in FHM type 1, a variant of the disease caused by a mutation in CACNA1A, which encodes the α1A subunit of the P/Q-type voltage-gated calcium channel.

Citation

Marta Kowalska, Michał Prendecki, Thomas Piekut, Wojciech Kozubski, Jolanta Dorszewska. Migraine: Calcium Channels and Glia. International journal of molecular sciences. 2021 Mar 07;22(5)