Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults.

B vitamers are co-enzymes involved in key physiological processes including energy production, one-carbon, and macronutrient metabolism. Studies profiling B vitamers simultaneously in parent-child dyads are scarce. Profiling B vitamers in parent-child dyads enables an insightful determination of gene-environment contributions to their circulating concentrations. We aimed to characterise: (a) parent-child dyad concordance, (b) generation (children versus adults), (c) age (within the adult subgroup (age range 28-71 years)) and (d) sex differences in plasma B vitamer concentrations in the CheckPoint study of Australian children. 1166 children (11 ± 0.5 years, 51% female) and 1324 parents (44 ± 5.1 years, 87% female) took part in a biomedical assessment of a population-derived longitudinal cohort study: The Growing Up in Australia's Child Health CheckPoint. B vitamer levels were quantified by UHPLC/MS-MS. B vitamer levels were weakly concordant between parent-child pairs (10-31% of variability explained). All B vitamer concentrations exhibited generation-specificity, except for flavin mononucleotide (FMN). The levels of thiamine, pantothenic acid, and 4-pyridoxic acid were higher in male children, and those of pantothenic acid were higher in male adults compared to their female counterparts. Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.

Citation

Stephanie Andraos, Beatrix Jones, Clare Wall, Eric Thorstensen, Martin Kussmann, David Cameron-Smith, Katherine Lange, Susan Clifford, Richard Saffery, David Burgner, Melissa Wake, Justin O'Sullivan. Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults. Nutrients. 2021 Mar 02;13(3)

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PMID: 33801409

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