Mitochondrial Calcium Signaling in Pancreatic β-Cell.

Anna Weiser, Jerome N Feige, Umberto De Marchi

International journal of molecular sciences 2021 Mar 03

filter terms:

Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation. Here, we describe the role of mitochondrial calcium signaling in pancreatic β-cell function. We report the latest pharmacological and genetic findings, including the first mitochondrial calcium-targeted intervention strategies developed to modulate pancreatic β-cell function and their potential relevance in the context of diabetes.

Citation

Anna Weiser, Jerome N Feige, Umberto De Marchi. Mitochondrial Calcium Signaling in Pancreatic β-Cell. International journal of molecular sciences. 2021 Mar 03;22(5)