Biotransformation of Cortisone with Rhodococcus rhodnii: Synthesis of New Steroids.

Federico Zappaterra, Stefania Costa, Daniela Summa, Valerio Bertolasi, Bruno Semeraro, Paola Pedrini, Raissa Buzzi, Silvia Vertuani

Molecules (Basel, Switzerland) 2021 Mar 03

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Cortisone is a steroid widely used as an anti-inflammatory drug able to suppress the immune system, thus reducing inflammation and attendant pain and swelling at the site of an injury. Due to its numerous side effects, especially in prolonged and high-dose therapies, the development of the pharmaceutical industry is currently aimed at finding new compounds with similar activities but with minor or no side effects. Biotransformations are an important methodology towards more sustainable industrial processes, according to the principles of "green chemistry". In this work, the biotransformation of cortisone with Rhodococcus rhodnii DSM 43960 to give two new steroids, i.e., 1,9β,17,21-tetrahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11,20-dione and 1,9β,17,20β,21-pentahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11-one, is reported. These new steroids have been fully characterized.

Citation

Federico Zappaterra, Stefania Costa, Daniela Summa, Valerio Bertolasi, Bruno Semeraro, Paola Pedrini, Raissa Buzzi, Silvia Vertuani. Biotransformation of Cortisone with Rhodococcus rhodnii: Synthesis of New Steroids. Molecules (Basel, Switzerland). 2021 Mar 03;26(5)