Correlation Engine 2.0
Clear Search sequence regions

  • acetyl (1)
  • callithrix (1)
  • factor (2)
  • Fibronectins (2)
  • gene (1)
  • germ cell (4)
  • marmoset (1)
  • phase (1)
  • primates (4)
  • rhesus macaques (2)
  • seasons (1)
  • SIRT1 (16)
  • sirtuin (1)
  • spermatogenesis (4)
  • spermatogonia (3)
  • testis (4)
  • Sizes of these terms reflect their relevance to your search.

    The epigenetic mechanisms controlling germ cell development and differentiation are still not well understood. Sirtuin-1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD)-dependent histone deacetylase and belongs to the sirtuin family of deacetylases. It catalyzes the removal of acetyl groups from a number of protein substrates. Some studies reported a role of SIRT1 in the central and peripheral regulation of reproduction in various non-primate species. However, testicular SIRT1 expression and its possible role in the testis have not been analyzed in primates. Here, we document expression of SIRT1 in testes of different primates and some non-primate species. SIRT1 is expressed mainly in the cells of seminiferous tubules, particularly in germ cells. The majority of SIRT1-positive germ cells were in the meiotic and postmeiotic phase of differentiation. However, SIRT1 expression was also observed in selected premeiotic germ cells, i.e., spermatogonia. SIRT1 co-localized in spermatogonia with irisin, an endocrine factor specifically expressed in primate spermatogonia. In marmoset testicular explant cultures, SIRT1 transcript levels are upregulated by the addition of irisin as compared to untreated controls explants. Rhesus macaques are seasonal breeders with high testicular activity in winter and low testicular activity in summer. Of note, SIRT1 mRNA and SIRT1 protein expression are changed between nonbreeding (low spermatogenesis) and breeding (high spermatogenesis) season. Our data suggest that SIRT1 is a relevant factor for the regulation of spermatogenesis in primates. Further mechanistic studies are required to better understand the role of SIRT1 during spermatogenesis.


    Fazal Wahab, Ignacio Rodriguez Polo, Rüdiger Behr. SIRT1 Expression and Regulation in the Primate Testis. International journal of molecular sciences. 2021 Mar 22;22(6)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33809872

    View Full Text