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Cell migration is essential for the development and maintenance of multicellular organisms, contributing to embryogenesis, wound healing, immune response, and other critical processes. It is also involved in the pathogenesis of many diseases, including immune deficiency disorders and cancer metastasis. Recently, extracellular vesicles (EVs) have been shown to play important roles in cell migration. Here, we review recent studies describing the functions of EVs in multiple aspects of cell motility, including directional sensing, cell adhesion, extracellular matrix (ECM) degradation, and leader-follower behavior. We also discuss the role of EVs in migration during development and disease and the utility of imaging tools for studying the role of EVs in cell migration. Copyright © 2021 Elsevier Inc. All rights reserved.


Bong Hwan Sung, Carole A Parent, Alissa M Weaver. Extracellular vesicles: Critical players during cell migration. Developmental cell. 2021 Jul 12;56(13):1861-1874

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PMID: 33811804

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