Comparison of Plasma Components between Frozen Plasma and Fresh Frozen Plasma].

To compare the plasma components of frozen plasma (FP) and fresh frozen plasma (FFP). Twenty samples of FP and 20 samples of FFP from Beijing Red Cross Blood Center were randomly selected. Immediately after plasma melting, 12 plasma components including coagulation factor, fibrinolytic system and anticoagulation protein were detected, including activated partial thromboplastin time (APTT), prothrombin time (PT), coagulation factor Ⅷ (FⅧ) activity, coagulation factor Ⅴ (FⅤ) activity, fibrinogen(FIB) level, ADAMTS-13 activity, von Willebrand factor(vWF) activity, D-dimer (D-dimer, DD), fibrin degradation products (FDP), antithrombin (AT), protein C (PC), and protein S (PS). All these coagulation components between the two types of plasma were compared and analyzed. Compared with FFP, APTT in FP was significantly prolonged(t=3.428, P<0.01), and PT was also significantly prolonged(z=-2.140, P<0.05), and FⅧ activity was decreased (t=-3.372, P<0.01), but all in the reference range, and PS activity was decreased(t=-2.458，P＜0.05), there was no statistical difference in the other part between two types of plasma(P>0.05). FP can substitute FFP in the treatment of some diseases, although it is lack of some coagulation factors and anticoagulation protein.

Citation

Ran-Ran Qin, Rui-Qin Hou, Hong-Yan Yang, Yin-Ping Cui, Yu-Han Gao, Wen-Qin Tian, Kai-Yan Liu. Comparison of Plasma Components between Frozen Plasma and Fresh Frozen Plasma]. Zhongguo shi yan xue ye xue za zhi. 2021 Apr;29(2):615-619

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PMID: 33812440

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