Progress in Gene Therapy of Sickle Cell Disease Based on Hemoglobin F--Review].

Sickle cell disease (SCD) is a single gene genetic disease, which seriously threatens the life span and quality of patients. On the basis of the pathogenesis of SCD and the alternative therapy based on fetal hemoglobin F (HbF), the research progress of transcription factors involved in the regulation of HbF gene expression, such as BCL11A, ZBTB7A, KLF-1, c-MYB and SOX6, as well as the application of CRISPR / Cas9, TALEN, zinc finger nuclease and other gene editing technologies in this field has been made, providing a solid theoretical basis for the exploration of new treatment schemes for β- like hemoglobin diseases, such as sickle cell disease and β- thalassemia.

Citation

Hao Liang, Yun-Xia Wang, Xu-Yan Li, Ya-Qi Wang, Yan Su. Progress in Gene Therapy of Sickle Cell Disease Based on Hemoglobin F--Review]. Zhongguo shi yan xue ye xue za zhi. 2021 Apr;29(2):643-647

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PMID: 33812445

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