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Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.

Sarah N Lauder, Bart Vanhaesebroeck, Awen Gallimore

British journal of cancer 2021 Aug


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    Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice. © 2021. The Author(s).

    Citation

    Sarah N Lauder, Bart Vanhaesebroeck, Awen Gallimore. Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British journal of cancer. 2021 Aug;125(4):467-469

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    PMID: 33824480

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