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    To assess the effectiveness of nanopermethrin as a potential new formulation for pest and vector control. Permethrin nanoparticles were prepared by the ionic gelation method and its structure and the formulations were designed using Box-Behnken statistical technique. The effect of independent variables (Chitosan/Permethrin ratio, tripolyphosphate quantity, sonication time) on the properties of nanoparticles was investigated to determine the optimal formulation. The size of the nanoparticles ranged from 135.27 ± 5.88 to 539.5 ± 24.01 nm and the insecticide entrapment efficiency per cent (EE%) ranged from 7.72 ± 1.36 to 63.59 ± 3.17%. Anopheles stephensi larvae were then bioassayed with the nanopermethrin and compared with the results of the bioassay with the mother molecule of permethrin using a standard WHO-recommended mosquito larval bioassay kit. LC50 with permethrin and nanopermethrin on larvae of An. stephensi were 0.125 and 0.026 ppm showing a 4.8 times difference. The LC50 for permethrin and nanopermethrin on Culex pipiens were 0.003 and 0.00032 ppm, respectively, showing a 9.4-fold difference. Nanopermethrin is much more potent than its mother molecule against larvae of An. stephensi and Cx. pipiens. © 2021 John Wiley & Sons Ltd.

    Citation

    Pedram Ebrahimnejad, Seyed Hassan Nikookar, Mahmoud Fazeli-Dinan, Seyed Payman Ziapour, Ali Farmoudeh, Amirhossein Babaei, Ahmadali Enayati. Preparation, characterisation and comparative toxicity of nanopermethrin against Anopheles stephensi and Culex pipiens. Tropical medicine & international health : TM & IH. 2021 Apr 10


    PMID: 33837621

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