An update of the unceasingly growing and diverse AraC/XylS family of transcriptional activators.

Daniel Cortés-Avalos, Noemy Martínez-Pérez, Mario A Ortiz-Moncada, Aylin Juárez-González, Arturo A Baños-Vargas, Paulina Estrada-de Los Santos, Ernesto Pérez-Rueda, J Antonio Ibarra

FEMS microbiology reviews 2021 Sep 08

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Transcriptional factors play an important role in gene regulation in all organisms, especially in Bacteria. Here special emphasis is placed in the AraC/XylS family of transcriptional regulators. This is one of the most abundant as many predicted members have been identified and more members are added because more bacterial genomes are sequenced. Given the way more experimental evidence has mounded in the past decades, we decided to update the information about this captivating family of proteins. Using bioinformatics tools on all the data available for experimentally characterized members of this family, we found that many members that display a similar functional classification can be clustered together and in some cases they have a similar regulatory scheme. A proposal for grouping these proteins is also discussed. Additionally, an analysis of surveyed proteins in bacterial genomes is presented. Altogether, the current review presents a panoramic view into this family and we hope it helps to stimulate future research in the field. © The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.

Citation

Daniel Cortés-Avalos, Noemy Martínez-Pérez, Mario A Ortiz-Moncada, Aylin Juárez-González, Arturo A Baños-Vargas, Paulina Estrada-de Los Santos, Ernesto Pérez-Rueda, J Antonio Ibarra. An update of the unceasingly growing and diverse AraC/XylS family of transcriptional activators. FEMS microbiology reviews. 2021 Sep 08;45(5)