Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide.

Wentao Liu, Wei Huang, Qian Lin, Mei-Hsuan Tsai, Rui Zhang, Lijun Fan, Jack D Scott, Guansai Liu, Jinqiao Wan

Bioorganic & medicinal chemistry 2021 May 15

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A robust palladium-catalyzed hydroxycarbonylation of aryl halides on DNA has been developed. Instead of Mo(CO)6 as a source of carbon monoxide as previously described in the literature, chloroform was used as a surrogate in this report for the purpose of avoiding to use a large excess of molybdenum reagent which is not totally soluble in aqueous reaction mixtures. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Wentao Liu, Wei Huang, Qian Lin, Mei-Hsuan Tsai, Rui Zhang, Lijun Fan, Jack D Scott, Guansai Liu, Jinqiao Wan. Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide. Bioorganic & medicinal chemistry. 2021 May 15;38:116118