Redox-Neutral Tetrafluoroethylation of Aryl Alkynes with 1,1,2,2-Tetrafluoroethane Sulfonic Acid Leading to α-Tetrafluoroethylated Acetophenones.

Takuji Kawamoto, Kohki Noguchi, Ryotaro Takata, Rio Sasaki, Hiroshi Matsubara, Akio Kamimura

Chemistry (Weinheim an der Bergstrasse, Germany) 2021 Jul 02

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The redox-neutral tetrafluoroethylation of alkynes with 1,1,2,2-tetrafluroroethanesulfonic acid (TFESA) and azobis(isobutyronitrile) (AIBN) proceeds via the formation of vinyl tetrafluoroethanesulfonates followed by a radical tetrafluoroethylation. Experimental and theoretical results support an intermolecular reaction. © 2021 Wiley-VCH GmbH.

Citation

Takuji Kawamoto, Kohki Noguchi, Ryotaro Takata, Rio Sasaki, Hiroshi Matsubara, Akio Kamimura. Redox-Neutral Tetrafluoroethylation of Aryl Alkynes with 1,1,2,2-Tetrafluoroethane Sulfonic Acid Leading to α-Tetrafluoroethylated Acetophenones. Chemistry (Weinheim an der Bergstrasse, Germany). 2021 Jul 02;27(37):9529-9534