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    Tumor markers (TM) detection is of great significance in tumor screening, monitoring and treatment intervention, which puts forward higher requirements for its detection quality. TM traceability is very important in the process of reagent production and clinical laboratory testing, which can help improving the reliability and comparability of TM testing. Based on the current principles and classification system of metrology traceability in the world, this paper reviews the quality requirements of reference materials and reference measurement methods related to protein and nucleic acid of TM, as well as the problems existing in the international convention reference measurement procedure and traceability system of TM, so as to provide a new idea for the quality assurance work of TM detection.


    X Ke, L S Shen. Progress in the traceability of tumor marker detection]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2021 Apr 06;55(4):545-550

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    PMID: 33858070

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