Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".

Sandipan Ray, Utham K Valekunja, Alessandra Stangherlin, Steven A Howell, Ambrosius P Snijders, Gopinath Damodaran, Akhilesh B Reddy

Science (New York, N.Y.) 2021 Apr 16

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Ness-Cohn et al claim that our observations of transcriptional circadian rhythms in the absence of the core clock gene Bmal1 in mouse skin fibroblast cells are supported by inadequate evidence. They claim that they were unable to reproduce some of the original ﬁndings with their reanalysis. We disagree with their analyses and outlook. Copyright © 2021, American Association for the Advancement of Science.

Citation

Sandipan Ray, Utham K Valekunja, Alessandra Stangherlin, Steven A Howell, Ambrosius P Snijders, Gopinath Damodaran, Akhilesh B Reddy. Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1". Science (New York, N.Y.). 2021 Apr 16;372(6539)