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Abruzzi et al argue that transcriptome oscillations found in our study in the absence of Bmal1 are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating Bmal1-independent 24-hour molecular oscillations. Copyright © 2021, American Association for the Advancement of Science.


Sandipan Ray, Utham K Valekunja, Alessandra Stangherlin, Steven A Howell, Ambrosius P Snijders, Gopinath Damodaran, Akhilesh B Reddy. Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1". Science (New York, N.Y.). 2021 Apr 16;372(6539)

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PMID: 33859003

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