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    Ray et al (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1. Copyright © 2021, American Association for the Advancement of Science.


    Elan Ness-Cohn, Ravi Allada, Rosemary Braun. Comment on "Circadian rhythms in the absence of the clock gene Bmal1". Science (New York, N.Y.). 2021 Apr 16;372(6539)

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    PMID: 33859007

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