Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis.

The anti-cancer effects of Alisma canaliculatum extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cancer cell death was associated with Bcl-2, survivin and Bax level changes, and it activated caspase-3 and -9. In addition, it was involved in the activation of MAPKs and increased the reactive oxygen species (ROS). These results suggest that ACE induces apoptosis in AGS gastric cancer cells, and therefore, ACE may have the potential to treat gastric cancer. © The author(s).

Citation

Min Ji Kwon, Jeong Nam Kim, Joon Park, Yun Tai Kim, Min Jae Lee, Byung Joo Kim. Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis. International journal of medical sciences. 2021;18(10):2155-2161

PMID: 33859522

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