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    Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3 ) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems. © 2021 Wiley-VCH GmbH.


    Shevanuja Theivendran, Chengzhong Yu. Nanochemistry Modulates Intracellular Decomposition Routes of S-Nitrosothiol Modified Silica-Based Nanoparticles. Small (Weinheim an der Bergstrasse, Germany). 2021 May;17(21):e2007671

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    PMID: 33860647

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