Synthesis of styryl-linked fused dihydropyridines by catalyst-free multicomponent reactions.

Rahul Yadav, Tasneem Parvin, Anoop Kumar Panday, Lokman H Choudhury

Molecular diversity 2021 Nov

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Herein, we report a rapid catalyst-free three-component reaction of 2-hydroxy-1,4-naphthoquinone, cinnamaldehydes and 3-aminopyrazoles in ethanol medium under reflux conditions for the easy access of styryl-linked dihydropyridines fused with naphthoquinone and pyrazole moiety. A wide variety of cinnamaldehyde derivatives and 3-aminopyrazoles were found suitable for this three-component reaction. All the products were fully characterized by spectroscopic tools and by recording single crystal XRD of one of the product. Catalyst-free reaction conditions, short reaction time, good yields of the products, easy purification process, formation of three new bonds (Two C-C and one C-N) in one-pot and products having four different bioactive moieties are the notable features of this methodology. © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Citation

Rahul Yadav, Tasneem Parvin, Anoop Kumar Panday, Lokman H Choudhury. Synthesis of styryl-linked fused dihydropyridines by catalyst-free multicomponent reactions. Molecular diversity. 2021 Nov;25(4):2161-2169