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Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma.

Citation

Daniel Beilner, Christina Kuhn, Bernd P Kost, Theresa Vilsmaier, Aurelia Vattai, Till Kaltofen, Sven Mahner, Elisa Schmoeckel, Christian Dannecker, Julia Jückstock, Doris Mayr, Udo Jeschke, Helene Hildegard Heidegger. Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer. Archives of gynecology and obstetrics. 2021 Apr 16


PMID: 33861372

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