A facile, efficient, and chemoselective synthesis of allylic amides has been developed. Allyl bromides were used as the precursors activated by silver triflate. A Ritter-type reaction readily proceeded to give various allyl amides under mild conditions. The reaction protocol was also applicable to different nucleophilic partners to give a wide range of allyl-substituted products in the absence of a base.
Xiaodong Xiong, Jonathan Wong, Ying-Yeung Yeung. Silver Salt-Mediated Allylation Reactions Using Allyl Bromides. The Journal of organic chemistry. 2021 May 07;86(9):6974-6982
PMID: 33861601
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