Beclin-1 increases with obstructive sleep apnea severity.
Frédéric Schlemmer, Maéva Zysman, Bruno Ribeiro Baptista, Etienne Audureau, Ala Covali Noroc, Audrey Ridoux, Geneviève Derumeaux, Serge Adnot, Bernard Maitre, Philippe le Corvoisier, Sophie Lanone, Jorge Boczkowski, Laurent Boyer
Sleep medicine 2021 MayObstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis. Copyright © 2021. Published by Elsevier B.V.
Citation
Frédéric Schlemmer, Maéva Zysman, Bruno Ribeiro Baptista, Etienne Audureau, Ala Covali Noroc, Audrey Ridoux, Geneviève Derumeaux, Serge Adnot, Bernard Maitre, Philippe le Corvoisier, Sophie Lanone, Jorge Boczkowski, Laurent Boyer. Beclin-1 increases with obstructive sleep apnea severity. Sleep medicine. 2021 May;81:474-476
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PMID: 33872948
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