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    Fullerenol nanoparticles were found to significantly modulate the gut microbiota and selectively enrich the short-chain fatty acids (SCFAs) production by adjusting the gut microbacteria in mice models. In this research, we screened the C. butyricum from seven strains and investigated the interactions and mechanism between the C. butyricum and fullerenol NPs in vitro fermentation. The results shows that fullerenol NPs increased the amounts of acetate and butyrate of C. butyricum without significant bacteria growth in the complete medium. The activities of the butyryl-CoA: acetate CoA transferase (BUT), which are the main pathway to produce butyrate, were reduced while the activities of the butyrate kinase (BUK) were enhanced simultaneously. Surprisingly, fullerenol NPs promoted the growth of C. butyricum and L. lactis in low glucose medium, but they could not be direct carbon source in the culture. Moreover, when cocultured with C. butyricum and the bifidobacterial strains in fullerenols, the biomass and acetate production of C. butyricum were markedly increased while butyrate was decreased significantly.


    Hui Sun, Jiaxin Zhang, Jianglong Kong, Hui Yuan, Yuelan Liang, Kui Chen, Xue Bai, Yanan Chang, Juan Li, Gengmei Xing. Increased Production of Short-Chain Fatty Acids in Microbacteria Fermentation Treated by Fullerenols. Journal of nanoscience and nanotechnology. 2021 Oct 01;21(10):5352-5362

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    PMID: 33875129

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